[{"data":1,"prerenderedAt":68},["ShallowReactive",2],{"q-nurse-108-1-basic-medicine-061":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":37,"lastmod":67},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-108-1-基礎醫學-061","nurse-108-1-basic-medicine-061",108,1,61,"血管緊縮素轉換酶抑制劑（angiotensin converting enzyme inhibitor, ACEI）的降血壓作用機制，包括下列那一項？",{"A":15,"B":16,"C":17,"D":18},"減少 angiotensinogen 的代謝，降低全身血管阻力","直接抑制 AT1 受體，產生血管放鬆作用","抑制 angiotensin II 及 bradykinin 代謝","減少 aldosterone 分泌，導致利尿，降低心臟前負荷","D",null,[],"本題考點在血管收縮素轉換酶抑制劑（ACEI）的降壓機轉。ACEI 抑制 ACE，減少 angiotensin II 生成，進而減少醛固酮（aldosterone）分泌，使腎臟排鈉排水、循環容積下降、心臟前負荷減少而降壓，故選 D。A 稱減少 angiotensinogen 代謝有誤，作用於 angiotensinogen 的是腎素（renin）而非 ACE。B『直接抑制 AT1 受體』是血管收縮素受體阻斷劑（ARB）的機轉，非 ACEI。C 稱抑制 angiotensin II『及 bradykinin 代謝』有誤，ACEI 是減少 AngII 生成、並抑制 bradykinin 的分解使其堆積（而非抑制其生成），敘述把機轉混淆，故不選。","RAAS 軸：腎素將 angiotensinogen 轉為 AngI，ACE 再將 AngI 轉為強血管收縮劑 AngII，並降解 bradykinin。ACEI 因此雙重效果：①↓AngII → 血管舒張、↓醛固酮、↓交感；②bradykinin 堆積 → 血管舒張但也產生乾咳與血管性水腫。記憶：ACEI 乾咳與血管水腫來自 bradykinin，而 ARB 不影響 bradykinin 故較少乾咳。兩者皆禁用於懷孕與雙側腎動脈狹窄，並須注意高血鉀。",[25,28,31,33,35],{"term":26,"count":27},"醛固酮",6,{"term":29,"count":30},"ACE 抑制劑",5,{"term":32,"count":11},"腎素-血管收縮素-醛固酮系統",{"term":34,"count":11},"angiotensin II",{"term":36,"count":11},"bradykinin",[38,42,47,52,57,62],{"webId":39,"stem":40,"number":41,"year":10,"session":11},"nurse-108-1-basic-medicine-062","下列何種藥物，是藉由活化氯離子通道而增加腸道液體的釋放，用於治療慢性便祕？",62,{"webId":43,"stem":44,"number":45,"year":10,"session":46},"nurse-108-2-basic-medicine-078","下列何種不是常見感染皮膚、毛髮及指甲（cutaneous mycoses）的黴菌？",78,2,{"webId":48,"stem":49,"number":50,"year":51,"session":46},"nurse-109-2-basic-medicine-012","有關排尿，副交感神經興奮會造成下列何種現象？",12,109,{"webId":53,"stem":54,"number":55,"year":56,"session":46},"nurse-110-2-basic-medicine-050","Cabamazepine 主要作用於下列何種離子通道（ion channel），而用於 partial seizure 之治療？",50,110,{"webId":58,"stem":59,"number":60,"year":61,"session":11},"nurse-112-1-basic-medicine-044","下列何種致病菌不是主要經由呼吸道感染人體？",44,112,{"webId":63,"stem":64,"number":65,"year":66,"session":46},"nurse-113-2-basic-medicine-038","長期口服 prednisone 之病人最常出現下列何種副作用？",38,113,"2026-09-04",1788510708606]