[{"data":1,"prerenderedAt":66},["ShallowReactive",2],{"q-nurse-108-1-basic-medicine-059":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":35,"lastmod":65},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-108-1-基礎醫學-059","nurse-108-1-basic-medicine-059",108,1,59,"下列 NSAIDs 藥物中，何者產生出血的機會最低？",{"A":15,"B":16,"C":17,"D":18},"Celecoxib","Ibuprofen","Indomethacin","Diclofenac","A",null,[],"本題考點在 NSAIDs 出血風險與環氧化酶（COX）選擇性的關係。血小板凝集靠 COX-1 生成的血栓素 A₂（TXA₂），選擇性抑制 COX-2 而不抑制血小板 COX-1 者出血風險最低；依此選 A Celecoxib，它為選擇性 COX-2 抑制劑，不影響血小板功能，出血機會最低。B Ibuprofen、C Indomethacin、D Diclofenac 皆為非選擇性 NSAIDs，同時抑制 COX-1，抑制 TXA₂ 使血小板凝集下降並傷胃黏膜，出血風險較高，故三者皆不選。","COX-1 是體質型（保護胃黏膜、維持腎血流、血小板 TXA₂）；COX-2 為誘導型（發炎部位前列腺素）。選擇性 COX-2 抑制劑（Celecoxib）保留 COX-1，胃腸與出血副作用少，但因抑制血管內皮 PGI₂ 而不抑制 TXA₂，反使血栓與心血管事件風險上升。記憶：COX-2 選擇性藥『腸胃較安全、心血管較危險』。相對地，Aspirin 不可逆乙醯化血小板 COX-1，抗血小板作用維持整個血小板壽命約 7–10 天。",[25,28,30,32,33],{"term":26,"count":27},"血栓素 A2",3,{"term":29,"count":11},"NSAIDs",{"term":31,"count":11},"COX-1\u002FCOX-2 選擇性",{"term":15,"count":11},{"term":34,"count":11},"血小板凝集",[36,40,45,50,55,60],{"webId":37,"stem":38,"number":39,"year":10,"session":11},"nurse-108-1-basic-medicine-060","Beta 腎上腺素受體拮抗劑用於治療心律不整，主要的藥理機轉為何？",60,{"webId":41,"stem":42,"number":43,"year":10,"session":44},"nurse-108-2-basic-medicine-076","關於梭狀芽孢桿菌（Clostridium ）的敘述，下列何者錯誤？",76,2,{"webId":46,"stem":47,"number":48,"year":49,"session":44},"nurse-109-2-basic-medicine-010","房室結（atrioventricular node）位於心臟的何處？",10,109,{"webId":51,"stem":52,"number":53,"year":54,"session":44},"nurse-110-2-basic-medicine-048","下列那一種關節炎是好發於年輕男性的薦腸骨關節及 HLA-B27 呈陽性？",48,110,{"webId":56,"stem":57,"number":58,"year":59,"session":11},"nurse-112-1-basic-medicine-042","補體活化路徑中所產生的膜攻擊複合體（membrane attack complex）包含了下列何者？",42,112,{"webId":61,"stem":62,"number":63,"year":64,"session":44},"nurse-113-2-basic-medicine-036","Clopidogrel 抑制血小板凝集的作用機制為何？",36,113,"2026-09-04",1788510708597]