[{"data":1,"prerenderedAt":67},["ShallowReactive",2],{"q-nurse-108-1-basic-medicine-055":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":36,"lastmod":66},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-108-1-基礎醫學-055","nurse-108-1-basic-medicine-055",108,1,55,"生物製劑之蛋白質藥物 Etanercept 可治療風濕性關節炎（Rheumatoid arthritis），此藥物之藥理作用為何？",{"A":15,"B":16,"C":17,"D":18},"結合淋巴激素 IL-2","結合腫瘤壞死因子 TNF-α","結合干擾素 IFN-α","結合前列腺素 PGs","B",null,[],"本題考點是生物製劑 Etanercept 的分子標靶。依其結構，Etanercept 是可溶性 TNF-α 受體（p75）與 IgG Fc 的融合蛋白，會結合並中和循環中的腫瘤壞死因子 TNF-α，阻斷其促發炎訊號，用於類風濕性關節炎，故選 B。A 結合 IL-2 為 Basiliximab 類抗 IL-2 受體製劑的方向，非 Etanercept。C 結合干擾素 IFN-α 並非其標靶，臨床上反而有以 IFN 為藥物者。D 結合前列腺素 PGs 是 NSAIDs 抑制環氧化酶下游的概念，與生物製劑無關，皆不選。","抗 TNF 生物製劑對比：Etanercept 是『受體誘餌』融合蛋白；Infliximab、Adalimumab、Golimumab 為抗 TNF-α 單株抗體；Certolizumab 為 PEG 化 Fab 片段。共同副作用是增加感染風險，用藥前須篩檢潛伏結核與 B 型肝炎。記憶：字尾『-cept』多為受體融合蛋白（receptor-Fc），『-mab』為單株抗體。TNF-α 是類風濕性關節炎滑膜發炎與骨侵蝕的核心細胞激素。",[25,28,30,32,34],{"term":26,"count":27},"類風濕性關節炎",3,{"term":29,"count":27},"生物製劑",{"term":31,"count":11},"Etanercept",{"term":33,"count":11},"腫瘤壞死因子 TNF-α",{"term":35,"count":11},"受體融合蛋白",[37,41,46,51,56,61],{"webId":38,"stem":39,"number":40,"year":10,"session":11},"nurse-108-1-basic-medicine-056","下列何者為 pilocarpine 的拮抗劑？",56,{"webId":42,"stem":43,"number":44,"year":10,"session":45},"nurse-108-2-basic-medicine-072","下列對病毒的敘述何者錯誤？",72,2,{"webId":47,"stem":48,"number":49,"year":50,"session":45},"nurse-109-2-basic-medicine-006","消化道的梅氏神經叢（Meissner’s plexus）位於下列何處？",6,109,{"webId":52,"stem":53,"number":54,"year":55,"session":45},"nurse-110-2-basic-medicine-044","關於良性（benign）腫瘤的敘述，下列何者最不適當？",44,110,{"webId":57,"stem":58,"number":59,"year":60,"session":11},"nurse-112-1-basic-medicine-038","下列何種藥物可降低腸道中水分的分泌，用於治療旅行時之腹瀉？",38,112,{"webId":62,"stem":63,"number":64,"year":65,"session":45},"nurse-113-2-basic-medicine-032","有關全身性麻醉劑 propofol，下列敘述何者正確？",32,113,"2026-09-04",1788510708560]