[{"data":1,"prerenderedAt":67},["ShallowReactive",2],{"q-nurse-107-2-basic-medicine-071":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":36,"lastmod":66},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-107-2-基礎醫學-071","nurse-107-2-basic-medicine-071",107,2,71,"Bordetella pertussis 造成百日咳的病程中，那一時期菌量最高，也最具傳染力？",{"A":15,"B":16,"C":17,"D":18},"潛伏期（incubation period）","黏膜期（catarrhal phase）","陣發期（paroxysmal phase）","恢復期（convalescent phase）","B",null,[],"本題考點在於百日咳的病程分期與傳染力。依微生物學，Bordetella pertussis 感染分潛伏、黏膜（catarrhal）、陣發（paroxysmal）、恢復四期，其中黏膜期菌量最高、症狀類似感冒而不易警覺，故此時傳染力最強，選 B。A 錯，潛伏期尚未大量繁殖排菌。C 錯，陣發期出現典型雞鳴樣咳，但此時免疫反應已致組織傷害、菌量與傳染力反而下降。D 錯，恢復期咳嗽漸緩、菌量最低，傳染力已明顯減弱。","分期記憶「黏膜期最毒、陣發期最咳」：黏膜期 1–2 週像普通感冒，卻是散播高峰，故家戶接觸者常在此期被傳染。陣發期的痙攣性咳與吸氣哮鳴（whoop）源自毒素（pertussis toxin、tracheal cytotoxin）造成的纖毛損傷與神經敏感化，非活菌大量存在。治療黃金期在黏膜期給 macrolide（如 azithromycin），愈晚給藥對縮短病程效益愈小。",[25,28,30,32,34],{"term":26,"count":27},"Bordetella pertussis",1,{"term":29,"count":27},"黏膜期",{"term":31,"count":27},"百日咳病程分期",{"term":33,"count":27},"傳染力",{"term":35,"count":27},"pertussis toxin",[37,41,46,51,56,61],{"webId":38,"stem":39,"number":40,"year":10,"session":11},"nurse-107-2-basic-medicine-072","針對淋病雙球菌（Neisseria gonorrhoeae ）造成的疾病，下列何者錯誤？",72,{"webId":42,"stem":43,"number":44,"year":45,"session":11},"nurse-108-2-basic-medicine-008","下列何者分泌不足可能導致呆小症（cretinism）？",8,108,{"webId":47,"stem":48,"number":49,"year":50,"session":27},"nurse-109-1-basic-medicine-022","下列關於牽張反射（stretch reflex）之敘述，何者正確？",22,109,{"webId":52,"stem":53,"number":54,"year":55,"session":27},"nurse-110-1-basic-medicine-060","下列何種藥物是經由抑制多巴胺受體（dopamine receptor）而產生止吐作用，可用以治療化療藥物所造成之噁心嘔吐？",60,110,{"webId":57,"stem":58,"number":59,"year":60,"session":11},"nurse-111-2-basic-medicine-024","18 歲的男病人至醫院門診，表示自己吃了海鮮後皮膚癢且出現蕁麻疹，此病人最有可能發生：",24,111,{"webId":62,"stem":63,"number":64,"year":65,"session":27},"nurse-113-1-basic-medicine-018","下列何者調控並可加速肝臟分泌膽汁？",18,113,"2026-09-04",1788510723969]