[{"data":1,"prerenderedAt":68},["ShallowReactive",2],{"q-nurse-107-2-basic-medicine-070":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":37,"lastmod":67},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-107-2-基礎醫學-070","nurse-107-2-basic-medicine-070",107,2,70,"臘腸桿菌毒素（Botulinum toxin）可以用於美容除皺之機制為何？",{"A":15,"B":16,"C":17,"D":18},"阻止乙醯膽鹼的釋放","使施打處之肌肉壞死","造成神經傳遞物質 GABA 無法釋放","使神經末稍接受器被破壞","A",null,[],"本題考點在於肉毒桿菌毒素的神經肌肉作用機轉。依生理學，Botulinum toxin 切割神經肌肉接合處突觸前的 SNARE 蛋白，阻止乙醯膽鹼（ACh）囊泡釋放，使肌肉無法收縮而放鬆、達到除皺效果，故選 A。B 錯，其作用是阻斷神經傳導使肌肉「暫時性麻痺」而非使肌肉壞死。C 錯，它阻斷的是 ACh 而非抑制性傳遞物 GABA。D 錯，毒素作用於突觸前的釋放機制，而非破壞突觸後的接受器。","SNARE 記憶：肉毒桿菌毒素（BoNT）切 SNAP-25／syntaxin／VAMP，破壤囊泡融合；破傷風毒素（tetanospasmin）則專切抑制性中間神經元的 VAMP，兩者機轉相似但臨床相反——肉毒＝弛緩性麻痺、破傷風＝痙攣性麻痺。醫美用 BoNT-A 阻斷表情肌 ACh 釋放而撫平動態皺紋；效果 3–6 個月消退，因軸突芽生重建新的釋放位點。",[25,28,30,32,35],{"term":26,"count":27},"神經肌肉接合處",5,{"term":29,"count":11},"乙醯膽鹼釋放",{"term":31,"count":11},"SNARE 蛋白",{"term":33,"count":34},"Botulinum toxin",1,{"term":36,"count":34},"弛緩性麻痺",[38,42,47,52,57,62],{"webId":39,"stem":40,"number":41,"year":10,"session":11},"nurse-107-2-basic-medicine-071","Bordetella pertussis 造成百日咳的病程中，那一時期菌量最高，也最具傳染力？",71,{"webId":43,"stem":44,"number":45,"year":46,"session":11},"nurse-108-2-basic-medicine-007","有關竇狀隙（sinusoid）的敘述，下列何者錯誤？",7,108,{"webId":48,"stem":49,"number":50,"year":51,"session":34},"nurse-109-1-basic-medicine-021","出生後，骨骼肌（skeletal muscle）受損傷或死亡，下列那一種細胞可進行修補？",21,109,{"webId":53,"stem":54,"number":55,"year":56,"session":34},"nurse-110-1-basic-medicine-059","Nitroglycerin（NTG）經由舌下或經皮膚（貼劑）給藥的目的為何？",59,110,{"webId":58,"stem":59,"number":60,"year":61,"session":11},"nurse-111-2-basic-medicine-023","有關靜脈血栓的敘述，下列何者最不適當？",23,111,{"webId":63,"stem":64,"number":65,"year":66,"session":34},"nurse-113-1-basic-medicine-017","下列有關卵巢內成熟濾泡（mature follicle）的敘述，何者錯誤？",17,113,"2026-09-04",1788510723964]