[{"data":1,"prerenderedAt":69},["ShallowReactive",2],{"q-nurse-107-2-basic-medicine-063":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":38,"lastmod":68},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-107-2-基礎醫學-063","nurse-107-2-basic-medicine-063",107,2,63,"在治療過敏性氣喘（allergic asthma）的藥物中，生物製劑之抗體藥物 omalizumab 其主要作用為何？",{"A":15,"B":16,"C":17,"D":18},"結合免疫球蛋白 IgE","結合免疫球蛋白 IgG","結合淋巴激素 IL-2","結合腫瘤壞死因子 TNF-α","A",null,[],"本題考點在於生物製劑 omalizumab 的分子標靶。依免疫學，過敏性氣喘屬第一型過敏反應，關鍵在 IgE 與肥大細胞表面 FcεRI 結合後引發去顆粒化；omalizumab 為抗 IgE 單株抗體，結合游離 IgE 的 Fc 段、阻止其接上受體，從源頭中斷過敏級聯，故選 A。B 錯，IgG 非過敏性氣喘的致病抗體。C 錯，IL-2 是 T 細胞增生相關激素，非本藥標靶（抗 IL-2 用於免疫抑制）。D 錯，TNF-α 抑制劑用於類風濕性關節炎等自體免疫病，與 omalizumab 機轉不同。","生物製劑對照記憶：omalizumab＝anti-IgE（過敏性氣喘、慢性蕁麻疹）；mepolizumab\u002Freslizumab＝anti-IL-5（嗜酸性球型氣喘）；dupilumab＝anti-IL-4Rα（第二型發炎）；anti-TNF-α（etanercept、adalimumab）＝自體免疫。命名尾綴 -mab 代表 monoclonal antibody。IgE 半衰期短、血中濃度低，故 anti-IgE 能有效清除，降低肥大細胞與嗜鹼性球的活化閾值。",[25,28,31,33,36],{"term":26,"count":27},"第一型過敏反應",12,{"term":29,"count":30},"生物製劑",3,{"term":32,"count":11},"FcεRI",{"term":34,"count":35},"omalizumab",1,{"term":37,"count":35},"anti-IgE 單株抗體",[39,43,48,53,58,63],{"webId":40,"stem":41,"number":42,"year":10,"session":11},"nurse-107-2-basic-medicine-064","下列何種免疫製劑，可以阻斷病毒複製及增強宿主免疫力，在臨床上用於治療 B 型肝炎？",64,{"webId":44,"stem":45,"number":46,"year":47,"session":35},"nurse-108-1-basic-medicine-080","下列那一寄生蟲的生活史中不需經血液循環到肺，就能到達寄生部位發育成成蟲？",80,108,{"webId":49,"stem":50,"number":51,"year":52,"session":35},"nurse-109-1-basic-medicine-014","下列何者不是常見的神經傳導物質（neurotransmitter）？",14,109,{"webId":54,"stem":55,"number":56,"year":57,"session":35},"nurse-110-1-basic-medicine-052","高血壓用藥 furosemide 在分類上屬於下列何者？",52,110,{"webId":59,"stem":60,"number":61,"year":62,"session":11},"nurse-111-2-basic-medicine-016","河豚毒素（tetrodotoxin）對神經細胞最主要的影響為何？",16,111,{"webId":64,"stem":65,"number":66,"year":67,"session":35},"nurse-113-1-basic-medicine-010","調節消化道平滑肌收縮，最主要的離子為下列何者？",10,113,"2026-09-04",1788510723897]