[{"data":1,"prerenderedAt":67},["ShallowReactive",2],{"q-nurse-107-2-basic-medicine-062":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":36,"lastmod":66},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-107-2-基礎醫學-062","nurse-107-2-basic-medicine-062",107,2,62,"有關藥物併用的敘述，下列何者錯誤？",{"A":15,"B":16,"C":17,"D":18},"aminoglycosides 與 loop diuretics 併用時，會增加病人聽覺損傷的機率","抗生素與口服避孕藥一起使用時，可能降低避孕藥的避孕效果","penicillins 與 aminoglycosides 併用具有協同作用（synergistic effect）","臨床上常併用 amoxicillin 與 carbapenem，以避免 amoxicillin 被 β-lactamase 分解","D",null,[],"本題考點在於抗生素併用的交互作用。依 β-lactam 藥理，amoxicillin 之所以易被 β-lactamase 水解，臨床是加入 β-lactamase 抑制劑（如 clavulanic acid）保護，而非併用 carbapenem，且 carbapenem 本身即耐 β-lactamase、無需靠 amoxicillin，兩者併用並無此設計，故 D 為錯誤敘述，即本題答案。A 正確，aminoglycosides 與 loop diuretics 皆具耳毒性，併用會加乘聽力損傷。B 正確，部分抗生素干擾腸肝循環或腸道菌叢，降低口服避孕藥效。C 正確，penicillins 破壞細胞壁使 aminoglycosides 更易進入菌體，具協同作用。","協同記憶：細胞壁抑制劑（penicillin）＋蛋白質合成抑制劑（aminoglycoside）＝經典 synergy，臨床用於腸球菌心內膜炎。β-lactamase 對策有二：一是換用耐酶藥（carbapenem、cephalosporin 第三代以上），二是加抑制劑（clavulanate、sulbactam、tazobactam）。耳毒性疊加要對照腎毒性——aminoglycoside 同時具腎、耳雙毒性，與 loop diuretic 併用時內耳外淋巴電解質紊亂使毛細胞受損。",[25,28,30,32,34],{"term":26,"count":27},"β-lactamase",1,{"term":29,"count":27},"clavulanic acid",{"term":31,"count":27},"aminoglycoside 耳毒性",{"term":33,"count":27},"抗生素協同作用",{"term":35,"count":27},"口服避孕藥交互作用",[37,41,46,51,56,61],{"webId":38,"stem":39,"number":40,"year":10,"session":11},"nurse-107-2-basic-medicine-063","在治療過敏性氣喘（allergic asthma）的藥物中，生物製劑之抗體藥物 omalizumab 其主要作用為何？",63,{"webId":42,"stem":43,"number":44,"year":45,"session":27},"nurse-108-1-basic-medicine-079","黴菌與人類細胞在結構上最大的差別為何？",79,108,{"webId":47,"stem":48,"number":49,"year":50,"session":27},"nurse-109-1-basic-medicine-013","有關胰臟之敘述何者錯誤？",13,109,{"webId":52,"stem":53,"number":54,"year":55,"session":27},"nurse-110-1-basic-medicine-051","阿司匹靈（Aspirin）與下列何種藥物併用會增加血中濃度，而使危險性提高？",51,110,{"webId":57,"stem":58,"number":59,"year":60,"session":11},"nurse-111-2-basic-medicine-015","體制素（somatostatin）主要由消化道何處分泌？",15,111,{"webId":62,"stem":63,"number":64,"year":65,"session":27},"nurse-113-1-basic-medicine-009","正常吸氣的過程中，不會出現下列何種情況？",9,113,"2026-09-04",1788510723892]