[{"data":1,"prerenderedAt":64},["ShallowReactive",2],{"q-nurse-107-2-basic-medicine-057":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":33,"lastmod":63},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":26},"nurse-107-2-基礎醫學-057","nurse-107-2-basic-medicine-057",107,2,57,"下列抗血小板凝集藥物中，何者之作用機制為抑制磷酸雙酯酶（phosphodiesterase）？",{"A":15,"B":16,"C":17,"D":18},"aspirin","ticlopidine","clopidogrel","dipyridamole","D",null,[],"本題考點是抗血小板藥的作用機轉分類。依藥理學,dipyridamole 的抗血小板機轉是抑制磷酸雙酯酶（phosphodiesterase),使血小板內 cAMP 分解減少、濃度上升而抑制血小板活化,並兼抑制腺苷再攝取,故選 D。A aspirin 是抑制環氧化酶減少血栓素 A2。B ticlopidine 與 C clopidogrel 同屬阻斷血小板 ADP 受體（P2Y12)的抗血小板藥,並非抑制磷酸雙酯酶。各藥標的不同,是本題鑑別重點。","抗血小板機轉四類記憶:①COX 抑制→血栓素↓＝aspirin;②ADP（P2Y12)受體阻斷＝clopidogrel、ticlopidine、prasugrel、ticagrelor;③磷酸雙酯酶抑制→cAMP↑＝dipyridamole、cilostazol;④GPIIb\u002FIIIa 受體拮抗＝abciximab、tirofiban。cAMP 上升會抑制血小板內鈣訊號與活化,故 PDE 抑制劑抗血小板。dipyridamole 常與 aspirin 併用於次級中風預防。cilostazol 同機轉,用於周邊動脈疾病間歇性跛行。可連結:cAMP 訊息、P2Y12、雙重抗血小板治療。",[25,27,29,31],{"term":18,"count":26},1,{"term":28,"count":26},"磷酸雙酯酶抑制",{"term":30,"count":26},"cAMP 上升抑制血小板",{"term":32,"count":26},"抗血小板藥機轉分類",[34,38,43,48,53,58],{"webId":35,"stem":36,"number":37,"year":10,"session":11},"nurse-107-2-basic-medicine-058","一位年輕人時常服用止痛劑來緩解頭痛，最近發現有胃潰瘍情形，下列何種藥物比較有效改善此種胃潰瘍現象？",58,{"webId":39,"stem":40,"number":41,"year":42,"session":26},"nurse-108-1-basic-medicine-074","T 細胞與 B 細胞的交互作用能增強宿主對抗微生物的防禦。下列何者不需要 T 細胞的參與？",74,108,{"webId":44,"stem":45,"number":46,"year":47,"session":26},"nurse-109-1-basic-medicine-008","下列何者具複層扁平上皮？",8,109,{"webId":49,"stem":50,"number":51,"year":52,"session":26},"nurse-110-1-basic-medicine-046","克林氏潰瘍（Curling ulcer）最容易發生在那種病人身上？",46,110,{"webId":54,"stem":55,"number":56,"year":57,"session":11},"nurse-111-2-basic-medicine-010","有關舌乳頭之敘述，下列何者正確？",10,111,{"webId":59,"stem":60,"number":61,"year":62,"session":26},"nurse-113-1-basic-medicine-004","帕金森氏症（Parkinson's disease）的顫抖症狀肇因為何？",4,113,"2026-09-04",1788510723835]