[{"data":1,"prerenderedAt":64},["ShallowReactive",2],{"q-nurse-107-2-basic-medicine-052":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":33,"lastmod":63},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":26},"nurse-107-2-基礎醫學-052","nurse-107-2-basic-medicine-052",107,2,52,"下列何種抗癲癇藥物對突觸小泡蛋白（synaptic vesicle protein, SV2A）的親和力最高？",{"A":15,"B":16,"C":17,"D":18},"oxcarbazepine","levetiracetam","phenytoin","felbamate","B",null,[],"本題考點是抗癲癇藥的分子作用標的。依神經藥理學,levetiracetam 的獨特機轉是結合突觸小泡蛋白 SV2A,調節神經傳導物質釋放而抑制異常放電,對 SV2A 親和力最高,故選 B。A oxcarbazepine 與 C phenytoin 主要阻斷電壓依賴性鈉離子通道,穩定神經細胞膜,並非作用於 SV2A。D felbamate 主要與 NMDA 受體阻斷及 GABA 增強有關,亦非 SV2A。levetiracetam 因作用機轉獨特、藥物交互作用少,是臨床常用的新型抗癲癇藥。","機轉分類記憶:鈉通道阻斷＝phenytoin、carbamazepine、oxcarbazepine、lamotrigine;增強 GABA＝benzodiazepines、phenobarbital、vigabatrin;鈣通道（T 型)＝ethosuximide（失神性發作首選);獨特 SV2A 結合＝levetiracetam。SV2A 位於突觸小泡膜,參與神經傳導物質的胞吐釋放,levetiracetam 藉此穩定過度放電。臨床優點:口服吸收好、不經肝 CYP 代謝、交互作用少,故廣泛使用。字尾記憶:「-racetam」與 SV2A 連結。可連結:癲癇發作類型與藥物選擇、鈉／鈣通道。",[25,27,29,31],{"term":16,"count":26},1,{"term":28,"count":26},"突觸小泡蛋白 SV2A",{"term":30,"count":26},"抗癲癇藥機轉分類",{"term":32,"count":26},"鈉通道阻斷對比",[34,38,43,48,53,58],{"webId":35,"stem":36,"number":37,"year":10,"session":11},"nurse-107-2-basic-medicine-053","下列何種抗精神病藥物最容易導致心電圖 QT 波延長？",53,{"webId":39,"stem":40,"number":41,"year":42,"session":26},"nurse-108-1-basic-medicine-069","披衣菌（Chlamydia spp.）有兩種型態，其中何者具感染力？",69,108,{"webId":44,"stem":45,"number":46,"year":47,"session":26},"nurse-109-1-basic-medicine-003","下列何者不是星狀細胞（astrocytes）的功能？",3,109,{"webId":49,"stem":50,"number":51,"year":52,"session":26},"nurse-110-1-basic-medicine-041","下列細胞形態或胞器的改變，何者是屬於細胞可逆性的損傷？",41,110,{"webId":54,"stem":55,"number":56,"year":57,"session":11},"nurse-111-2-basic-medicine-005","下列何者傳送頸動脈竇受器所感受血壓改變的訊息？",5,111,{"webId":59,"stem":60,"number":61,"year":62,"session":46},"nurse-112-3-basic-medicine-049","恐水症（hydrophobia）症狀的病人，是感染下列何種病毒的特殊病徵？",49,112,"2026-09-04",1788510723777]