[{"data":1,"prerenderedAt":65},["ShallowReactive",2],{"q-nurse-107-1-basic-medicine-056":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":64},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":11},"nurse-107-1-基礎醫學-056","nurse-107-1-basic-medicine-056",107,1,56,"下列抗癌藥物中，何者對細胞週期之 M 期有專一性抑制作用？",{"A":15,"B":16,"C":17,"D":18},"cyclophosphamide","bleomycin","vincristine","5-fluorouracil","C",null,[],"本題考點是抗癌藥的細胞週期專一性。vincristine 屬 vinca 生物鹼,結合 tubulin 抑制微管聚合,使有絲分裂中期紡錘體無法形成,對細胞週期 M 期具專一抑制,故選 C。A cyclophosphamide 為烷化劑,交聯 DNA,屬細胞週期非專一性;B bleomycin 造成 DNA 斷裂,作用偏 G2 期;D 5-fluorouracil 抑制 thymidylate synthase 干擾 DNA 合成,作用於 S 期,均非 M 期專一。","細胞週期專一性記憶:S 期→抗代謝劑(5-FU、methotrexate、cytarabine);M 期→紡錘體毒(vinca 生物鹼抑制微管聚合、taxane 穩定微管阻止解聚);G2 期→bleomycin、etoposide。非週期專一→烷化劑、抗腫瘤抗生素(doxorubicin)。vincristine 神經毒性(周邊神經病變)明顯但骨髓抑制較輕,vinblastine 則相反。記憶:『vin-卡 M 期、紫杉也卡 M 期』。",[25,26,28,30,32],{"term":17,"count":11},{"term":27,"count":11},"vinca 生物鹼",{"term":29,"count":11},"微管\u002F紡錘體",{"term":31,"count":11},"M 期專一性",{"term":33,"count":11},"細胞週期抗癌藥分類",[35,39,44,49,54,59],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-107-1-basic-medicine-057","下列何者屬於 Class III 抗心律不整藥物兼具有 β-blocker 作用？",57,{"webId":40,"stem":41,"number":42,"year":10,"session":43},"nurse-107-2-basic-medicine-073","下列何種細菌較容易引起抗生素相關腹瀉（antibiotic-associated diarrhea）？",73,2,{"webId":45,"stem":46,"number":47,"year":48,"session":43},"nurse-108-2-basic-medicine-007","有關竇狀隙（sinusoid）的敘述，下列何者錯誤？",7,108,{"webId":50,"stem":51,"number":52,"year":53,"session":43},"nurse-109-2-basic-medicine-045","關於自體免疫性胃炎（autoimmune gastritis）之敘述，下列何者錯誤？",45,109,{"webId":55,"stem":56,"number":57,"year":58,"session":11},"nurse-111-1-basic-medicine-009","下列器官的主要養分來源，何者不是來自髂內動脈？",9,111,{"webId":60,"stem":61,"number":62,"year":63,"session":43},"nurse-112-2-basic-medicine-023","粥狀硬化（Atherosclerosis）引起的動脈瘤最常發生於何處？",23,112,"2026-09-04",1788510701413]