[{"data":1,"prerenderedAt":65},["ShallowReactive",2],{"q-nurse-107-1-basic-medicine-054":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":64},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-107-1-基礎醫學-054","nurse-107-1-basic-medicine-054",107,1,54,"在耳鼻喉科與家醫科門診，針對過敏性鼻炎與氣喘患者，處方以 Zileuton 治療，此藥物主要抑制下列何種酵素？",{"A":15,"B":16,"C":17,"D":18},"cyclooxygenase（COX）","angiotensin-converting enzyme（ACE）","lipoxygenase（LOX）","adenylate cyclase（AC）","C",null,[],"本題考點是 Zileuton 的酵素抑制標的。Zileuton 抑制 5-lipoxygenase(LOX),阻斷花生四烯酸轉化為白三烯(leukotrienes),減少支氣管收縮與發炎,用於氣喘與過敏性鼻炎,故選 C。A cyclooxygenase(COX)是 NSAID 與 aspirin 的標的,產生前列腺素而非白三烯;B angiotensin-converting enzyme(ACE)是降血壓 ACE 抑制劑的標的;D adenylate cyclase(AC)催化 cAMP 生成,與白三烯路徑無關,均非 Zileuton 作用點。","花生四烯酸兩大分支:走 COX→前列腺素\u002F血栓素;走 LOX→白三烯(LTB4 趨化、LTC4\u002FD4\u002FE4 造成支氣管收縮與血管通透)。Zileuton 抑 5-LOX 減少白三烯生成;另一類抗白三烯藥 montelukast\u002Fzafirlukast 則阻斷白三烯受體(CysLT1)。記憶:『-leuton 擋合成、-lukast 擋受體』。對比 aspirin 抑 COX 反而使花生四烯酸更多流向 LOX,可誘發 aspirin 敏感性氣喘。",[25,28,30,32],{"term":26,"count":27},"花生四烯酸代謝",3,{"term":29,"count":11},"Zileuton",{"term":31,"count":11},"5-lipoxygenase(LOX)",{"term":33,"count":11},"白三烯(leukotrienes)",[35,39,44,49,54,59],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-107-1-basic-medicine-055","有關第一代 H 1 組織胺（histamine）受體拮抗劑（如 Chlorpheniramine 與 Diphenhydramine），其主要副作用之敘述，下列何者錯誤？",55,{"webId":40,"stem":41,"number":42,"year":10,"session":43},"nurse-107-2-basic-medicine-071","Bordetella pertussis 造成百日咳的病程中，那一時期菌量最高，也最具傳染力？",71,2,{"webId":45,"stem":46,"number":47,"year":48,"session":43},"nurse-108-2-basic-medicine-005","脾臟的血液主要來自下列何者的分枝？",5,108,{"webId":50,"stem":51,"number":52,"year":53,"session":43},"nurse-109-2-basic-medicine-043","下列那一種細胞不參與過敏性氣喘？",43,109,{"webId":55,"stem":56,"number":57,"year":58,"session":11},"nurse-111-1-basic-medicine-007","下列何者不是淋巴組織？",7,111,{"webId":60,"stem":61,"number":62,"year":63,"session":43},"nurse-112-2-basic-medicine-021","一位 18 歲男性因四肢水腫而就醫。他被發現有明顯蛋白尿和高血脂，但是腎臟功能和血壓均正常。腎臟切片的光學顯微鏡檢查顯示正常腎小球構造，但電子顯微鏡檢查發現足細胞（podocyte）突起消失。引起此病人水腫的最可能機轉為下列何者？",21,112,"2026-09-04",1788510701385]