[{"data":1,"prerenderedAt":66},["ShallowReactive",2],{"q-nurse-107-1-basic-medicine-051":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":36,"lastmod":65},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-107-1-基礎醫學-051","nurse-107-1-basic-medicine-051",107,1,51,"Diazepam 與 GABA 受體結合後，會增加何種離子的傳導，使細胞膜穩定，而作為抗焦慮藥（anxiolytic drug）？",{"A":15,"B":16,"C":17,"D":18},"鈣","氯","鉀","鈉","B",null,[],"本題考點是 benzodiazepine 的作用離子機轉。Diazepam 結合於 GABA-A 受體上的 benzodiazepine 位點,增強 GABA 開啟氯離子(Cl⁻)通道的頻率,使氯離子內流造成細胞膜過極化而穩定,達抗焦慮效果,故選 B。A 鈣離子與神經傳導物釋放及肌肉收縮相關,非此機轉;C 鉀離子外流雖也能過極化,但非 GABA-A\u002FBZD 的作用離子;D 鈉離子內流是去極化(興奮)方向,與抑制作用相反。","GABA-A 是配體門控氯離子通道:benzodiazepine 增加通道『開啟頻率』,barbiturate 則延長『開啟時間』,兩者皆放大 GABA 的抑制性氯離子電流。氯離子內流→膜過極化→神經元較難興奮=鎮靜、抗焦慮、抗癲癇、肌肉鬆弛。記憶:『BZD 管次數、巴比妥管時間』。過量可用 flumazenil(BZD 受體拮抗劑)逆轉。",[25,28,30,32,34],{"term":26,"count":27},"GABA-A 受體",5,{"term":29,"count":11},"Diazepam",{"term":31,"count":11},"氯離子通道",{"term":33,"count":11},"膜過極化",{"term":35,"count":11},"benzodiazepine 機轉",[37,41,46,50,55,60],{"webId":38,"stem":39,"number":40,"year":10,"session":11},"nurse-107-1-basic-medicine-052","下列何者是治療恐慌症（panic disorders）之首選用藥？",52,{"webId":42,"stem":43,"number":44,"year":10,"session":45},"nurse-107-2-basic-medicine-068","有關人類主要組織相容性複合體（MHC）分子的敘述，下列何者正確？",68,2,{"webId":47,"stem":48,"number":45,"year":49,"session":45},"nurse-108-2-basic-medicine-002","有關表皮的敘述，下列何者錯誤？",108,{"webId":51,"stem":52,"number":53,"year":54,"session":45},"nurse-109-2-basic-medicine-040","下列何種變化最可能發生在凋亡（apoptosis）的細胞？",40,109,{"webId":56,"stem":57,"number":58,"year":59,"session":11},"nurse-111-1-basic-medicine-004","肺臟內進行氣體交換的呼吸膜（respiratory membrane）構造，主要是由那兩種細胞與結締組織共同構成？",4,111,{"webId":61,"stem":62,"number":63,"year":64,"session":45},"nurse-112-2-basic-medicine-018","尿素和下列那一種物質的累積會造成腎臟髓質組織間的高滲透度（ hyperosmolar medullary renal interstitium）？",18,112,"2026-09-04",1788510701365]