[{"data":1,"prerenderedAt":62},["ShallowReactive",2],{"q-nurse-107-1-basic-medicine-049":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":32,"lastmod":61},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":11},"nurse-107-1-基礎醫學-049","nurse-107-1-basic-medicine-049",107,1,49,"下列何者最能產生肝臟酵素誘導作用（enzyme induction）？",{"A":15,"B":16,"C":17,"D":18},"phenobarbital","cimetidine","ketoconazole","erythromycin","A",null,[],"本題考點是肝臟藥物代謝酵素的誘導與抑制。phenobarbital 是典型的肝臟 cytochrome P450 酵素誘導劑,可增加 CYP 表現而加速自身與併用藥物的代謝,故選 A。B cimetidine、C ketoconazole、D erythromycin 三者相反,都是常見的 P450 抑制劑——cimetidine 廣泛抑制多種 CYP、ketoconazole 強力抑制 CYP3A4、erythromycin 亦抑制 CYP3A4,會使併用藥物血中濃度上升,故非酵素誘導劑。","常見酵素誘導劑記憶:『巴比妥、Rifampin、Phenytoin、Carbamazepine、慢性酒精、抽菸』,會降低併用藥療效(如使避孕藥失效、warfarin 需增量)。常見抑制劑:『cimetidine、ketoconazole(-azole 類)、macrolide(erythromycin)、grapefruit juice、valproate』,會使併用藥毒性上升。誘導需數天到數週生效(需新酵素合成),抑制多為即時競爭。",[25,27,29,30],{"term":26,"count":11},"肝臟酵素誘導",{"term":28,"count":11},"cytochrome P450",{"term":15,"count":11},{"term":31,"count":11},"CYP 抑制劑(cimetidine\u002Fketoconazole\u002Ferythromycin)",[33,37,42,47,52,56],{"webId":34,"stem":35,"number":36,"year":10,"session":11},"nurse-107-1-basic-medicine-050","下列何者為 succinylcholine 的副作用？",50,{"webId":38,"stem":39,"number":40,"year":10,"session":41},"nurse-107-2-basic-medicine-066","下列何者是抗體的功能？",66,2,{"webId":43,"stem":44,"number":45,"year":46,"session":11},"nurse-108-1-basic-medicine-080","下列那一寄生蟲的生活史中不需經血液循環到肺，就能到達寄生部位發育成成蟲？",80,108,{"webId":48,"stem":49,"number":50,"year":51,"session":41},"nurse-109-2-basic-medicine-038","有關威爾斯瘤（Wilms tumor）之敘述，下列何者正確？",38,109,{"webId":53,"stem":54,"number":41,"year":55,"session":11},"nurse-111-1-basic-medicine-002","低血鈣主要會刺激那一個內分泌腺體的激素分泌，以增加血鈣濃度？",111,{"webId":57,"stem":58,"number":59,"year":60,"session":41},"nurse-112-2-basic-medicine-016","過敏性休克的特徵為何？",16,112,"2026-09-04",1788510701323]