[{"data":1,"prerenderedAt":63},["ShallowReactive",2],{"q-nurse-106-2-basic-medicine-064":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":62},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-106-2-基礎醫學-064","nurse-106-2-basic-medicine-064",106,2,64,"免疫抑制劑 sirolimus（又稱 rapamune）可緩解免疫組織損壞。此藥物在淋巴細胞作用之敘述，何者正確？",{"A":15,"B":16,"C":17,"D":18},"降低 calcineurin 的活性","減少淋巴激素（IL-2）產生","抑制 mTOR，影響細胞週期","抑制 purine 生合成","C",null,[],"本題考點為免疫抑制劑 sirolimus(rapamune)的作用機轉。sirolimus 與 FKBP12 結合後抑制 mTOR,阻斷 IL-2 驅動的下游訊號,使 T 細胞停在 G1 期無法進入 S 期,影響細胞週期,選 C。A 降低 calcineurin 活性為 cyclosporine、tacrolimus 的機轉。B 減少 IL-2 產生亦屬 calcineurin 抑制劑作用。D 抑制 purine 生合成為 azathioprine、mycophenolate,均與 sirolimus 不同。","細節易混:tacrolimus 與 sirolimus 都結合 FKBP12,但下游不同——tacrolimus 抑制 calcineurin(擋 IL-2『生產』),sirolimus 抑制 mTOR(擋 IL-2『反應』與細胞週期推進)。故兩者機轉互補而非重複。mTOR 抑制常見副作用為高血脂與傷口癒合不良。記憶:calcineurin 阻『造 IL-2』、mTOR 阻『用 IL-2』。",[25,28,30,32],{"term":26,"count":27},"mTOR 抑制",1,{"term":29,"count":27},"sirolimus",{"term":31,"count":27},"FKBP12",{"term":33,"count":27},"細胞週期 G1 期停滯",[35,39,43,48,53,58],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-106-2-basic-medicine-065","主要辨識革蘭氏陰性菌的脂多糖（lipopolysaccharide）的細胞受體是那一種？",65,{"webId":40,"stem":41,"number":27,"year":42,"session":11},"nurse-107-2-basic-medicine-001","蘭氏細胞（Langerhans’cell）主要功能為何？",107,{"webId":44,"stem":45,"number":46,"year":47,"session":27},"nurse-108-1-basic-medicine-015","下列何者位於延腦的錐體（pyramids）？",15,108,{"webId":49,"stem":50,"number":51,"year":52,"session":27},"nurse-109-1-basic-medicine-053","下列何者可用於預防和改善暈車和暈船（motion sickness）作用？",53,109,{"webId":54,"stem":55,"number":56,"year":57,"session":11},"nurse-110-2-basic-medicine-017","有關骨骼肌與心肌收縮的比較，下列敘述何者正確？",17,110,{"webId":59,"stem":60,"number":27,"year":61,"session":27},"nurse-112-1-basic-medicine-001","腦下腺腫瘤影響視覺功能時，下列何處最可能受壓迫？",112,"2026-09-04",1788510696760]