[{"data":1,"prerenderedAt":65},["ShallowReactive",2],{"q-nurse-106-2-basic-medicine-063":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":64},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":11},"nurse-106-2-基礎醫學-063","nurse-106-2-basic-medicine-063",106,2,63,"下列何者是抗生素 quinolones 藥物的作用機轉？",{"A":15,"B":16,"C":17,"D":18},"抑制細胞壁生合成","抑制蛋白質生合成","抑制葉酸生合成","抑制 DNA gyrase 作用","D",null,[],"本題考點為 quinolones(氟喹諾酮)的抗菌機轉。此類藥物抑制細菌 DNA gyrase(第二型拓樸異構酶)與拓樸異構酶 IV,阻斷 DNA 複製時的超螺旋解旋與分離,選 D。A 抑制細胞壁生合成為 β-內醯胺類與 vancomycin 的機轉。B 抑制蛋白質生合成為胺基醣苷、四環黴素、巨環類等。C 抑制葉酸生合成為 sulfonamide 與 trimethoprim,均非 quinolones 的作用點。","DNA gyrase 負責在複製時導入負超螺旋、解除拓樸壓力,拓樸異構酶 IV 則分離子代染色體;quinolones 卡住酶-DNA 複合物造成致死性斷裂。革蘭氏陰性菌主標的為 gyrase,陽性菌多為拓樸異構酶 IV。抗菌機轉常五分類:細胞壁、蛋白質、葉酸、DNA、細胞膜,quinolones 歸『DNA』。記憶:quinolone=『解旋酶殺手』。",[25,27,30,32],{"term":26,"count":11},"DNA gyrase",{"term":28,"count":29},"拓樸異構酶 IV",1,{"term":31,"count":29},"氟喹諾酮 quinolones",{"term":33,"count":29},"DNA 複製抑制",[35,39,44,49,54,59],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-106-2-basic-medicine-064","免疫抑制劑 sirolimus（又稱 rapamune）可緩解免疫組織損壞。此藥物在淋巴細胞作用之敘述，何者正確？",64,{"webId":40,"stem":41,"number":42,"year":43,"session":29},"nurse-107-1-basic-medicine-080","在精神病院、難民營和擁擠的日間照護中心，要特別注意下列那種寄生蟲的感染？",80,107,{"webId":45,"stem":46,"number":47,"year":48,"session":29},"nurse-108-1-basic-medicine-014","位於禽距裂（calcarine fissure）上、下兩側的大腦皮質與下列何種感覺最有關？",14,108,{"webId":50,"stem":51,"number":52,"year":53,"session":29},"nurse-109-1-basic-medicine-052","下列何種藥物可抑制 tumor tyrosine kinase 活性，因而可用於 chronic myeloid leukemia 及 gastrointestinal stromal tumor？",52,109,{"webId":55,"stem":56,"number":57,"year":58,"session":11},"nurse-110-2-basic-medicine-016","股神經（femoral nerve）受損，最可能發生下列何種情形？",16,110,{"webId":60,"stem":61,"number":62,"year":63,"session":11},"nurse-111-2-basic-medicine-050","生食野生動物的內臟較易感染下列何種絛蟲？",50,111,"2026-09-04",1788510696739]