[{"data":1,"prerenderedAt":66},["ShallowReactive",2],{"q-nurse-106-2-basic-medicine-053":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":35,"lastmod":65},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-106-2-基礎醫學-053","nurse-106-2-basic-medicine-053",106,2,53,"Carbidopa 與 levodopa 併用於巴金森氏症患者之治療，主要是因為 carbidopa 抑制下列何種酶所致？",{"A":15,"B":16,"C":17,"D":18},"乙醯膽鹼酶（acetylcholine esterase）","多巴脫羧酶（DOPA decarboxylase）","多巴胺羧化酶（dopamine beta-hydroxylase）","單胺氧化酶（monoamine oxidase）","B",null,[],"本題考點為 carbidopa 的藥理作用。levodopa 在周邊會被多巴脫羧酶(DOPA decarboxylase)轉為多巴胺,而多巴胺無法通過血腦障壁又造成周邊噁心、低血壓等副作用;carbidopa 抑制周邊此酶,使更多 levodopa 進入腦中才轉化,故選 B。A 乙醯膽鹼酶與膽鹼分解有關,非本藥標的。C 多巴胺羧化酶(dopamine β-hydroxylase)催化多巴胺轉正腎上腺素,方向錯誤。D 單胺氧化酶是 MAO 抑制劑的標的,而非 carbidopa。","carbidopa 本身不過血腦障壁,故只抑制『周邊』的芳香族胺基酸脫羧酶,不影響腦內轉換,合併後可將 levodopa 用量降約 75%、減少周邊副作用並提高中樞可用量。同理 entacapone 抑制周邊 COMT 亦是延長 levodopa 半衰期。記憶對比:carbidopa 擋『脫羧』、entacapone 擋『甲基化(COMT)』,兩者都是為了讓 levodopa 多進腦。",[25,28,30,33],{"term":26,"count":27},"血腦障壁",7,{"term":29,"count":11},"carbidopa",{"term":31,"count":32},"DOPA decarboxylase 多巴脫羧酶",1,{"term":34,"count":32},"levodopa 周邊代謝",[36,40,45,50,55,60],{"webId":37,"stem":38,"number":39,"year":10,"session":11},"nurse-106-2-basic-medicine-054","下列用於 sleep disorders 之藥物，何者可明顯縮短入睡時間及減少睡眠中醒來次數，但會造成病人有白天中樞抑制（daytime sedation）之副作用？",54,{"webId":41,"stem":42,"number":43,"year":44,"session":32},"nurse-107-1-basic-medicine-070","下列何者是李斯特菌（Listeria monocytogenes）主要傳染途徑？",70,107,{"webId":46,"stem":47,"number":48,"year":49,"session":32},"nurse-108-1-basic-medicine-004","上臂觸摸肱動脈脈搏的位置為下列何處？",4,108,{"webId":51,"stem":52,"number":53,"year":54,"session":32},"nurse-109-1-basic-medicine-042","若家族中有第二型糖尿病的病史，罹患糖尿病的機會也將比較高。第二型糖尿病的遺傳模式屬於：",42,109,{"webId":56,"stem":57,"number":58,"year":59,"session":11},"nurse-110-2-basic-medicine-006","有關消化道肌肉層的敘述，下列何者正確？",6,110,{"webId":61,"stem":62,"number":63,"year":64,"session":11},"nurse-111-2-basic-medicine-040","Imatinib 是慢性骨髓性白血病（chronic myeloid leukemia）的標靶療法用藥，下列何者為其作用機轉？",40,111,"2026-09-04",1788510696642]