[{"data":1,"prerenderedAt":64},["ShallowReactive",2],{"q-nurse-106-1-basic-medicine-057":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":33,"lastmod":63},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":11},"nurse-106-1-基礎醫學-057","nurse-106-1-basic-medicine-057",106,1,57,"下列有關新型抗凝血藥物 Argatroban 的敘述，何者正確？",{"A":15,"B":16,"C":17,"D":18},"經由注射方式給藥","主要抑制第十凝血因子","血漿中必須有 antithrombin III 存在才有抗凝血活性","不經肝臟代謝直接由腎臟排除","A",null,[],"本題考點為新型抗凝血藥 Argatroban 的特性。依抗凝血藥理,Argatroban 為直接凝血酶(第二凝血因子)抑制劑,分子小可直接與凝血酶結合,採靜脈注射給藥,故正解為 A。其抑制的是凝血酶而非第十凝血因子(第十 a 抑制劑為 rivaroxaban 等),B 錯。作為直接抑制劑,不需 antithrombin III 存在即有活性,此點與 heparin 恰相反,C 錯。Argatroban 主要經肝臟代謝而非由腎臟排除,腎功能不全者仍可用,D 錯。","臨床定位:Argatroban 常用於肝素引起血小板低下症(HIT)患者,因不需 antithrombin III、不與血小板第四因子交叉。對比 heparin「需 ATIII、腎\u002F網狀內皮清除」,argatroban「不需 ATIII、肝代謝」,兩點是必記鑑別。",[25,27,29,31],{"term":26,"count":11},"Argatroban",{"term":28,"count":11},"直接凝血酶抑制劑",{"term":30,"count":11},"靜脈注射給藥",{"term":32,"count":11},"不需 antithrombin III",[34,38,43,48,53,58],{"webId":35,"stem":36,"number":37,"year":10,"session":11},"nurse-106-1-basic-medicine-058","下列緊急降血壓用藥，何者的藥效作用持續時間最短？",58,{"webId":39,"stem":40,"number":41,"year":10,"session":42},"nurse-106-2-basic-medicine-074","白色念珠菌（C. albicans）為正常菌群，但若在下列何處發現時，表示已受感染？",74,2,{"webId":44,"stem":45,"number":46,"year":47,"session":42},"nurse-107-2-basic-medicine-008","當細菌侵入體內，何種血球細胞會轉變成巨噬細胞以吞噬細菌？",8,107,{"webId":49,"stem":50,"number":51,"year":52,"session":42},"nurse-108-2-basic-medicine-046","關於肺塵埃沉著症（pneumoconiosis）的敘述，下列何者錯誤？",46,108,{"webId":54,"stem":55,"number":56,"year":57,"session":11},"nurse-110-1-basic-medicine-010","總膽管與胰管匯聚形成肝胰壺腹（hepatopancreatic ampulla），開口於下列何處？",10,110,{"webId":59,"stem":60,"number":61,"year":62,"session":11},"nurse-111-1-basic-medicine-044","下列那一項因素與波雷特氏食道（Barrett esophagus）發生腺癌（adenocarcinoma）最有關係？",44,111,"2026-09-04",1788510691425]