[{"data":1,"prerenderedAt":64},["ShallowReactive",2],{"q-nurse-106-1-basic-medicine-054":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":63},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-106-1-基礎醫學-054","nurse-106-1-basic-medicine-054",106,1,54,"抗焦慮用藥 benzodiazepine 的藥理作用機轉為何？",{"A":15,"B":16,"C":17,"D":18},"抑制中樞多巴胺的神經活性","阻斷鉀離子通道","活化 GABA-A 受體造成細胞過極化（hyperpolarization）","抑制腺苷（adenosine）的神經活性","C",null,[],"本題考點為苯二氮平類(benzodiazepine)的藥理作用機轉。依中樞神經藥理,benzodiazepine 結合 GABA-A 受體上的特定位點,增加氯離子通道的開啟頻率、促進氯離子內流使神經元過極化(hyperpolarization),進而增強 GABA 的抑制作用,故正解為 C。抑制中樞多巴胺活性是抗精神病藥的作用,非 BZD,A 錯。BZD 並非阻斷鉀離子通道,B 錯。抑制腺苷神經活性為咖啡因等的作用機轉,D 錯。","關鍵對比:benzodiazepine 增加氯通道「開啟頻率」,barbiturate 則延長「開啟時間」,兩者皆正向調節 GABA-A 但機轉不同,是經典鑑別題。過極化使神經不易達閾值放電,故產生抗焦慮、鎮靜、抗癲癇與肌肉鬆弛效果。解毒劑為 flumazenil。",[25,28,30,32],{"term":26,"count":27},"GABA-A 受體",5,{"term":29,"count":11},"Benzodiazepine",{"term":31,"count":11},"氯離子內流與過極化",{"term":33,"count":11},"與 barbiturate 機轉對比",[35,39,44,48,53,58],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-106-1-basic-medicine-055","下列何者屬於 thromboxane A 2 的藥理作用？",55,{"webId":40,"stem":41,"number":42,"year":10,"session":43},"nurse-106-2-basic-medicine-071","下列何者不是腸內桿菌的抗原？",71,2,{"webId":45,"stem":46,"number":27,"year":47,"session":43},"nurse-107-2-basic-medicine-005","下列何者是尺骨的表面標記？",107,{"webId":49,"stem":50,"number":51,"year":52,"session":43},"nurse-108-2-basic-medicine-043","下列感染症的致病機轉與細菌產生的外毒素有關，何者除外？",43,108,{"webId":54,"stem":55,"number":56,"year":57,"session":11},"nurse-110-1-basic-medicine-007","下列何者位於延髓（medulla oblongata）？",7,110,{"webId":59,"stem":60,"number":61,"year":62,"session":11},"nurse-111-1-basic-medicine-041","下列何種腦瘤最常見於小於 5 歲兒童的小腦？",41,111,"2026-09-04",1788510691396]