[{"data":1,"prerenderedAt":64},["ShallowReactive",2],{"q-nurse-106-1-basic-medicine-052":3},{"subject":4,"subjectSlug":5,"subjectFullName":6,"question":7,"related":34,"lastmod":63},"基礎醫學","basic-medicine","基礎醫學(包括解剖學、生理學、病理學、藥理學、微生物學與免疫學)",{"id":8,"webId":9,"year":10,"session":11,"subject":4,"number":12,"stem":13,"options":14,"answer":19,"answerNote":20,"images":21,"explanation":22,"explanationDeep":23,"topics":24,"freq":27},"nurse-106-1-基礎醫學-052","nurse-106-1-basic-medicine-052",106,1,52,"局部麻醉劑使用在發炎組織時其藥效降低，最主要的原因為何？",{"A":15,"B":16,"C":17,"D":18},"局部組織的 pH 值下降，使藥物的脂溶性降低","局部組織的 pH 值上升，使藥物的脂溶性降低","發炎因子干擾藥效","藥物在發炎組織易產生抗藥性","A",null,[],"本題考點為發炎組織降低局部麻醉劑藥效的原因。依局麻藥理,局部麻醉劑為弱鹼,需以非解離的脂溶型穿過神經細胞膜才能作用;發炎組織 pH 值下降(偏酸),使藥物更多解離為離子型、脂溶性降低而不易進入神經,藥效因而減弱,故正解為 A。選項 B 方向相反,發炎是 pH 下降而非上升,錯。發炎因子並非藥效下降的主要機轉,C 錯。局部麻醉劑藥效減弱屬酸鹼分配問題,並非產生抗藥性,D 錯。","Henderson-Hasselbalch 觀念:弱鹼在酸性環境解離增加,脂溶型比例下降。局麻藥須先以脂溶型入膜、再於軸內轉離子型阻斷鈉離子通道。臨床上膿瘍等酸性發炎區局麻常「打不麻」即源於此,是理解勝過死背的典型題。",[25,28,30,32],{"term":26,"count":27},"局部麻醉劑",3,{"term":29,"count":11},"弱鹼與脂溶型穿膜",{"term":31,"count":11},"發炎組織 pH 下降",{"term":33,"count":11},"Henderson-Hasselbalch",[35,39,44,48,53,58],{"webId":36,"stem":37,"number":38,"year":10,"session":11},"nurse-106-1-basic-medicine-053","長期使用抗精神病藥 Haloperidol，最易造成那種副作用？",53,{"webId":40,"stem":41,"number":42,"year":10,"session":43},"nurse-106-2-basic-medicine-069","婦女經期使用的衛生棉條不潔時，會引起毒性休克症候群，是下列何種細菌產生之毒素所引起的？",69,2,{"webId":45,"stem":46,"number":27,"year":47,"session":43},"nurse-107-2-basic-medicine-003","下列何者具有產生大量熱的功能？",107,{"webId":49,"stem":50,"number":51,"year":52,"session":43},"nurse-108-2-basic-medicine-041","50 歲女性，身材略微肥胖，且有糖尿病及高血壓的病史，最近因陰道出血就診。下列何種診斷的可能性最低？",41,108,{"webId":54,"stem":55,"number":56,"year":57,"session":11},"nurse-110-1-basic-medicine-005","下列關於紅血球（erythrocyte; RBC）的敘述，何者正確？",5,110,{"webId":59,"stem":60,"number":61,"year":62,"session":11},"nurse-111-1-basic-medicine-039","下列那一種腎臟腫瘤主要常見於 10 歲以下的小孩？",39,111,"2026-09-04",1788510691380]